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Article

Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.

Neuroscience letters - 19 Dec 2008

Alachkar Houda, Kataki Maria, Scharre Douglas W, Papp Audrey, Sadee Wolfgang

Abstract excerpt

Polymorphisms in the gene encoding SORL1, involved in cellular trafficking of APP, have been implicated in late-onset Alzheimer's disease, by a mechanism thought to affect mRNA expression. To search for regulatory polymorphisms, we have measured allele-specific mRNA expression of SORL1 in human autopsy tissues from the prefrontal cortex of 26 Alzheimer's patients, and 51 controls, using two synonymous marker SNPs...

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Identifiers

PMID: 18938222
DOI: 10.1016/j.neulet.2008.10.034
PMCID: PMC2612539

Genes

SORL1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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