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Article

Structure and function of a transcriptional network activated by the MAPK Hog1.

Nature genetics - 1 Nov 2008

Capaldi Andrew P, Kaplan Tommy, Liu Ying, Habib Naomi, Regev Aviv, Friedman Nir, O'Shea Erin K

Abstract excerpt

Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways...

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Source

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Identifiers

PMID: 18931682
DOI: 10.1038/ng.235
PMCID: PMC2825711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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