The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.

Abstract excerpt

We have analyzed the transcriptional response to osmotic shock in the yeast Saccharomyces cerevisiae. The mRNA level of 186 genes increased at least 3-fold after a shift to NaCl or sorbitol, whereas that of more than 100 genes was at least 1.5-fold diminished. Many induced genes encode proteins that presumably contribute to protection against different types of damage or encode enzymes in glycerol, trehalose, and...

Topics

• Adaptation, Biological
• DNA-Binding Proteins
• Gene Expression Profiling
• Gene Expression Regulation, Fungal
• Glycerol
• Models, Genetic
• Mutation
• Osmotic Pressure
• RNA, Fungal
• RNA, Messenger