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Article

Evaluating the evidence for transmission distortion in human pedigrees.

Genetics - 1 May 2012

Meyer Wynn K, Arbeithuber Barbara, Ober Carole, Ebner Thomas, Tiemann-Boege Irene, Hudson Richard R, Przeworski Molly

Abstract excerpt

Children of a heterozygous parent are expected to carry either allele with equal probability. Exceptions can occur, however, due to meiotic drive, competition among gametes, or viability selection, which we collectively term "transmission distortion" (TD). Although there are several well-characterized examples of these phenomena, their existence in humans remains unknown. We therefore performed a genome-wide scan...

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Identifiers

PMID: 22377632
DOI: 10.1534/genetics.112.139576
PMCID: PMC3338262

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