Article
Mismatch repair gene mutations in Chinese HNPCC patients.
Cytogenetic and genome research - 1 Jan 2008
Sheng J Q, Fu L, Sun Z Q, Huang J S, Han M, Mu H, Zhang H, Zhang Y Z, Zhang M Z, Li A Q, Wu Z T, Han Y, Li S R
Abstract excerpt
To explore the characteristics of DNA mismatch repair gene mutations in Chinese patients with hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome, the MLH1 and MSH2 genes from probands of 76 HNPCC families were sequenced. By doing so, two frame-shift mutations, three splice-site mutations and fourteen missense mutations (thirteen missense mutations and one nonsense mutation) were identified in...
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