Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer.

International journal of colorectal disease - 1 Aug 2007

Zheng Duo, Li Tiegang, Liu Xiaoping, Hu Weixin, Chen Hanchun, Yang Yongjia

Abstract excerpt

BACKGROUND AND AIMS: Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common hereditary colon cancer syndrome accounting for 1-5% of all colorectal cancer cases. Germline mutations in DNA mismatch repair (MMR) genes are associated with the clinical phenotype of HNPCC. Defects in the MSH2 gene may account for about 40% of HNPCC cases including nucleotide substitutions, deletions and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to Germ-Line Mutation

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Nuclear Proteins

Source

Identifiers

PMID: 17333219
DOI: 10.1007/s00384-006-0253-z

Genes

MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer.PMID 17333219Read ↗

A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Distinct mutations in MLH1 and MSH2 genes in hereditary non-polyposis colorectal cancer (HNPCC) families from China.Semantic proximity Read ↗

Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families.Semantic proximity Read ↗

[Mutation screening of MLH1 and MSH2 genes in two Chinese families with hereditary nonpolyposis colorectal cancer].Semantic proximity Read ↗

The analysis for identifying large DNA fragment aberrations of MSH2 and MLH1 genes from familial colorectal cancer in China.Semantic proximity Read ↗

Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families.Semantic proximity Read ↗

Novel germline and somatic mutations of the MSH2 gene in hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Diagnostic challenges in a CMMRD patient with a novel mutation in the PMS2 gene: a case report.Semantic proximity Read ↗

Genetics of hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population.Semantic proximity Read ↗

Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.