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Article

Distinct mutations in MLH1 and MSH2 genes in hereditary non-polyposis colorectal cancer (HNPCC) families from China.

BMB reports - 1 May 2011

Wei Wenqian, Liu Fangqi, Liu Lei, Li Zuofeng, Zhang Xiaoyan, Jiang Fan, Shi Qu, Zhou Xiaoyan, Sheng Weiqi, Cai Sanjun, Li Xuan, Xu Ye, Nan Peng

Abstract excerpt

Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China...

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Source

Identifiers

PMID: 21615986
DOI: 10.5483/BMBRep.2011.44.5.317

Genes

MLH1
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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