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Germline MSH2 and MLH1 mutational spectrum including large rearrangements in HNPCC families from Poland (update study)

13 Dec 2005

Abstract excerpt

Germline mutations in the DNA mismatch repair genes MSH2 and MLH1 account for a significant proportion of hereditary non-polyposis colorectal cancer (HNPCC) families. One approach by which development of an efficient DNA-testing procedure can be implemented is to describe the nature and frequency of common mutations in particular ethnic groups. Two hundred and twenty-six patients from families matching the...

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PMID: 16451135
DOI: 10.1111/j.1399-0004.2006.00550.x

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