Article
Effects of transforming growth factor-beta 1 on growth of aortic smooth muscle cells. Influences of interaction with growth factors, cell state, cell phenotype, and cell cycle.
Atherosclerosis - 1 Jun 1991
Morisaki N, Kawano M, Koyama N, Koshikawa T, Umemiya K, Saito Y, Yoshida S
Abstract excerpt
Transforming growth factor (TGF)-beta 1 may have different effects on cell proliferation depending on many conditions. This paper clarifies the effects of various conditions on the effect of TGF-beta 1 on proliferation of cultured rabbit aortic smooth muscle cells (SMC) and also the time of its action during the cell cycle. TGF-beta 1 at 10-10,000 pg/ml inhibited DNA synthesis of SMC in the G0 stage derived from...
Topics
- Animals
- Aorta, Thoracic
- Cell Cycle
- Cell Division
- Cells, Cultured
- DNA
- Fetal Blood
- Fibroblast Growth Factors
- Growth Substances
- Immunoblotting
- Muscle, Smooth, Vascular