Tumour necrosis factor-alpha can modulate the phenotype of aortic smooth muscle cells.

doi:10.3109/00365519309086626

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Article

Tumour necrosis factor-alpha can modulate the phenotype of aortic smooth muscle cells.

Scandinavian journal of clinical and laboratory investigation - 1 Jul 1993

Morisaki N, Xu Q P, Koshikawa T, Saito Y, Yoshida S, Ueda S

Abstract excerpt

In culture, rabbit aortic smooth muscle cells (SMC) from an atheroma differed phenotypically from SMC from normal media (M-SMC) in their growth rate, secretion of SMC-derived growth factor (SDGF), and metabolism of acetylated low density lipoproteins (a-LDL). The factor responsible for this in vivo phenotypic change of SMC was investigated in vitro. After preincubation of M-SMC with 0.1-10 U ml-1 of tumour...

Topics

Animals
Aorta
Cell Division
Cells, Cultured
DNA
Growth Substances
Lipoproteins, LDL
Male
Muscle, Smooth, Vascular
Phenotype
Rabbits
Tumor Necrosis Factor-alpha

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Open in PubMed

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PMID: 8378737
DOI: 10.3109/00365519309086626

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