Article
Cyclosporine A inhibits induction of DNA synthesis by PDGF and other peptide mitogens in cultured rat aortic smooth muscle cells and dermal fibroblasts.
Growth factors (Chur, Switzerland) - 1 Jan 1991
Thyberg J, Hansson G K
Abstract excerpt
The immunosuppressive drug cyclosporine A was recently shown to inhibit smooth muscle proliferation in the vascular response to injury. To examine if this may be due to a direct effect of the drug on the smooth muscle cells (SMCs), we have studied its influence on the phenotypic modulation of rat aortic SMCs in primary cultures and on the induction of DNA synthesis by peptide mitogens in serum-starved...
Topics
- Animals
- Aorta
- Cells, Cultured
- Cyclosporine
- DNA
- DNA Replication
- Fibroblasts
- Male
- Muscle Contraction
- Muscle, Smooth, Vascular
- Peptides
- Phenotype