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Article

Activation of PPAR-α induces cell cycle arrest and inhibits transforming growth factor-β1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.

Cellular signalling - 1 May 2013

Lien Sheng-Chieh, Wei Shu-Yi, Chang Shun-Fu, Chang Margaret Dah-Tsyr, Chang Jang-Yang, Chiu Jeng-Jiann

Abstract excerpt

Transforming growth factor-β1 (TGF-β1) regulates the cell cycle and the differentiation of mesenchymal cells into smooth muscle cells (SMCs). However, the precise intracellular signaling pathways involved in these processes have not been fully clarified. It has also been shown that there is an increase in TGF-β1 expression in human atherosclerotic plaques. Furthermore, peroxisome proliferator-activated receptors...

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PMID: 23385087
DOI: 10.1016/j.cellsig.2013.01.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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