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Article

Overexpression of p21Waf1 induces apoptosis in immortalized human vascular smooth muscle cells.

Journal of atherosclerosis and thrombosis - 1 Jan 2003

Kato Seiya, Ueda Seiji, Yamaguchi Miki, Miyamoto Tetsuya, Fujii Teruhiko, Izumaru Shinsuke, Kume Shinichiro, Toyozumi Yasuo, Arima Nobuyuki, Morimatsu Minoru

Abstract excerpt

To understand the role of the cell cycle regulatory protein in the control of smooth muscle cell (SMC) proliferation, we tested the overexpression of p21Waf1, a cyclin-dependent kinase inhibitor, in human normal (MS9) and immortalized SMCs (ISS10) transfected with ori-minus simian virus 40 DNA, using an adenovirus-mediated system. In MS9, overexpression of p21Waf1 resulted in the inhibition of cell cycle...

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Identifiers

PMID: 14566087
DOI: 10.5551/jat.10.239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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