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Article

Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation.

Circulation research - 1 Dec 1992

Holycross B J, Blank R S, Thompson M M, Peach M J, Owens G K

Abstract excerpt

Previously, we demonstrated that treatment of postconfluent quiescent rat aortic smooth muscle cells (SMCs) with platelet-derived growth factor (PDGF)-BB dramatically reduced smooth muscle (SM) alpha-actin synthesis. In the present studies, we focused on the expression of two other SM-specific proteins, SM myosin heavy chain (SM-MHC) and SM alpha-tropomyosin (SM-alpha TM), to determine whether the actions of...

Topics

Animals
Aorta
Autoradiography
Blotting, Northern
Cell Differentiation
Cells, Cultured
DNA
Electrophoresis, Gel, Two-Dimensional
Muscle, Smooth, Vascular
Myosins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet-Derived Growth Factor

RNA, Messenger

Rats

Tropomyosin

Source

Identifiers

PMID: 1423945
DOI: 10.1161/01.res.71.6.1525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1423945-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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