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Article

Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017

Brühmann Stefan, Ushakov Dmitry S, Winterhoff Moritz, Dickinson Richard B, Curth Ute, Faix Jan

Abstract excerpt

Ena/VASP proteins act as actin polymerases that drive the processive elongation of filament barbed ends in membrane protrusions or at the surface of bacterial pathogens. Based on previous analyses of fast and slow elongating VASP proteins by in vitro total internal reflection fluorescence microscopy (TIRFM) and kinetic and thermodynamic measurements, we established a kinetic model of Ena/VASP-mediated actin...

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Identifiers

PMID: 28667124
DOI: 10.1073/pnas.1703145114
PMCID: PMC5530675

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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