Article
Multiple actin binding domains of Ena/VASP proteins determine actin network stiffening.
European biophysics journal : EBJ - 1 Nov 2012
Gentry Brian S, van der Meulen Stef, Noguera Philippe, Alonso-Latorre Baldomero, Plastino Julie, Koenderink Gijsje H
Abstract excerpt
Vasodilator-stimulated phosphoprotein (Ena/VASP) is an actin binding protein, important for actin dynamics in motile cells and developing organisms. Though VASP's main activity is the promotion of barbed end growth, it has an F-actin binding site and can form tetramers, and so could additionally play a role in actin crosslinking and bundling in the cell. To test this activity, we performed rheology of...
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