Article
Specific pattern of RAS oncogene mutations in follicular thyroid tumors.
The Journal of clinical endocrinology and metabolism - 1 Jun 2003
Vasko V, Ferrand M, Di Cristofaro J, Carayon P, Henry J F, de Micco C
Abstract excerpt
The prevalence of H-RAS, K-RAS, and N-RAS gene mutations in thyroid tumors according to malignancy and histology is controversial. Differences in methodology and histological classifications may explain discrepant results. To address this issue, we first performed a pooled analysis of 269 mutations garnered from 39 previous studies. Mutations proved significantly less frequent when detected with direct sequencing...
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