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Article

Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis.

Hepatology (Baltimore, Md.) - 1 Jun 2002

Pascale Rosa M, Simile Maria M, De Miglio Maria R, Muroni Maria R, Calvisi Diego F, Asara Giuseppina, Casabona Daniela, Frau Maddalena, Seddaiu Maria A, Feo Francesco

Abstract excerpt

Preneoplastic and neoplastic hepatocytes undergo c-Myc up-regulation and overgrowth in rats genetically susceptible to hepatocarcinogenesis, but not in resistant rats. Because c-Myc regulates the pRb-E2F pathway, we evaluated cell cycle gene expression in neoplastic nodules and hepatocellular carcinomas (HCCs), induced by initiation/selection (IS) protocols 40 and 70 weeks after diethylnitrosamine treatment, in...

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Identifiers

PMID: 12029619
DOI: 10.1053/jhep.2002.33682

Genes

CDK2
CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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