Article
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
Diabetologia - 1 Dec 2008
Rafiq S, Melzer D, Weedon M N, Lango H, Saxena R, Scott L J, Palmer C N A, Morris A D, McCarthy M I, Ferrucci L, Hattersley A T, Zeggini E, Frayling T M
Abstract excerpt
AIMS/HYPOTHESIS: There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk. METHODS: We selected 46 variants: (1) eight variants known...
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