Article
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
BMC medical genetics - 6 Mar 2006
Smyth Deborah J, Howson Joanna M M, Payne Felicity, Maier Lisa M, Bailey Rebecca, Holland Kieran, Lowe Christopher E, Cooper Jason D, Hulme John S, Vella Adrian, Dahlman Ingrid, Lam Alex C, Nutland Sarah, Walker Neil M, Twells Rebecca C J, Todd John A
Abstract excerpt
BACKGROUND: The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease development. Some genes have been shown to affect several immune-mediated diseases. Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with...
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