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Article

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

The New England journal of medicine - 25 Dec 2008

Smyth Deborah J, Plagnol Vincent, Walker Neil M, Cooper Jason D, Downes Kate, Yang Jennie H M, Howson Joanna M M, Stevens Helen, McManus Ross, Wijmenga Cisca, Heap Graham A, Dubois Patrick C, Clayton David G, Hunt Karen A, van Heel David A, Todd John A

Abstract excerpt

BACKGROUND: Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared. METHODS: We evaluated the association between type 1 diabetes and eight loci related to the risk of celiac disease by genotyping and statistical...

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Share to Celiac Disease
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2 Receptor alpha Subunit

Share to LIM Domain Proteins

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 19073967
DOI: 10.1056/NEJMoa0807917
PMCID: PMC2840835

Genes

TAGAP
CTLA4
INS
LPP
PTPN2
PTPN22
RGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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