Cytokine profiles, genetic polymorphisms, and systemic inflammatory markers in type 1 diabetes patients with COVID-19: IL-18 a predictor of disease severity.

doi:10.3389/fimmu.2026.1736234

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Article

Cytokine profiles, genetic polymorphisms, and systemic inflammatory markers in type 1 diabetes patients with COVID-19: IL-18 a predictor of disease severity.

Frontiers in immunology - 1 Jan 2026

Abdullah Mohammed Yousif, Laaribi Ahmed Baligh, Babay Wafa, Alhaddad Farah Abdulkhaleq Khattab, Mehri Asma, Ouzari Hadda-Imene, Marghali Sonia

Abstract excerpt

Background: Patients with Type 1 Diabetes Mellitus (T1DM) are at increased risk for severe COVID-19 due to chronic inflammation, immune dysregulation, and impaired antiviral responses. However, the combined contribution of cytokine imbalance, host genetic variation, and systemic inflammation on COVID-19 severity in this population remains incompletely understood. This study aimed to investigate inflammatory...

Topics

Humans
Diabetes Mellitus, Type 1
Male
Female
Adult
Interleukin-18
COVID-19
Severity of Illness Index
Biomarkers
SARS-CoV-2
Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Inflammation

Young Adult

Polymorphism, Genetic

Source

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Identifiers

PMID: 41846929
DOI: 10.3389/fimmu.2026.1736234
PMCID: PMC12989528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41846929-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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