Article
Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes.
BMC medical genetics - 14 Jul 2011
Arora Paul, Garcia-Bailo Bibiana, Dastani Zari, Brenner Darren, Villegas Andre, Malik Suneil, Spector Timothy D, Richards Brent, El-Sohemy Ahmed, Karmali Mohamed, Badawi Alaa
Abstract excerpt
BACKGROUND: Type 2 diabetes mellitus (T2DM) has been linked to a state of pre-clinical chronic inflammation resulting from abnormalities in the innate immune pathway. Serum levels of pro-inflammatory cytokines and acute-phase proteins, collectively known as 'inflammatory network', are elevated in the pre-, or early, stages of T2DM and increase with disease progression. Genetic variation can affect the innate...
Topics
- Acute-Phase Proteins
- Blood Glucose
- Body Mass Index
- C-Reactive Protein
- Cholesterol
- Cross-Sectional Studies
- Cytokines
- Diabetes Mellitus, Type 2
- Female
- Humans