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Article

Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes.

BMC medical genetics - 14 Jul 2011

Arora Paul, Garcia-Bailo Bibiana, Dastani Zari, Brenner Darren, Villegas Andre, Malik Suneil, Spector Timothy D, Richards Brent, El-Sohemy Ahmed, Karmali Mohamed, Badawi Alaa

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2DM) has been linked to a state of pre-clinical chronic inflammation resulting from abnormalities in the innate immune pathway. Serum levels of pro-inflammatory cytokines and acute-phase proteins, collectively known as 'inflammatory network', are elevated in the pre-, or early, stages of T2DM and increase with disease progression. Genetic variation can affect the innate...

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PMID: 21756351
DOI: 10.1186/1471-2350-12-95
PMCID: PMC3161932

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