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Article

The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.

Nucleic acids research - 1 Oct 2012

Nandi Saikat, Whitby Matthew C

Abstract excerpt

In fission yeast, the DNA helicase Fml1, which is an orthologue of human FANCM, is a key component of the machinery that drives and governs homologous recombination (HR). During the repair of DNA double-strand breaks by HR, it limits the occurrence of potentially deleterious crossover recombinant...

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Source

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Identifiers

PMID: 22844101
DOI: 10.1093/nar/gks715
PMCID: PMC3479183

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22844101-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.PMID 22844101Read ↗

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.Semantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.Semantic proximity Read ↗

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.Semantic proximity Read ↗

The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.Semantic proximity Read ↗

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male miceSemantic proximity Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.Semantic proximity Read ↗

The translocation activity of Rad54 reduces crossover outcomes during homologous recombination.Semantic proximity Read ↗

The FANCM family of DNA helicases/translocasesSemantic proximity Read ↗

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