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Article

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer.

Oncogene - 15 Jan 2009

Crane C A, Panner A, Murray J C, Wilson S P, Xu H, Chen L, Simko J P, Waldman F M, Pieper R O, Parsa A T

Abstract excerpt

Immune escape describes a critical event whereby tumor cells adopt an immunoresistant phenotype to escape adaptive surveillance. We show that expression of a pivotal negative regulator of T-cell function, B7-H1, correlates with PI(3) kinase activation in breast and prostate cancer patients. B7-H1-mediated immunoresistance can be attenuated by inhibitors of the PI(3) kinase pathway, and is dependent on...

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Source

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Identifiers

PMID: 18850006
DOI: 10.1038/onc.2008.384
PMCID: PMC3786571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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