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Article

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

1 Dec 2018

Abstract excerpt

Development of resistance to chemotherapy is a major obstacle in extending the survival of patients with cancer. Although originally defined as an immune checkpoint molecule, B7-H1 (also named as PD-L1 or CD274) was found to play a role in cancer chemoresistance; however, the underlying mechanism of action of B7-H1 in regulation of chemotherapy sensitivity remains unclear in cancer cells. Here we show that...

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PMID: 30603685
DOI: 10.1016/j.heliyon.2018.e01039

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