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Article

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.

Nature medicine - 1 Jan 2007

Parsa Andrew T, Waldron James S, Panner Amith, Crane Courtney A, Parney Ian F, Barry Jeffrey J, Cachola Kristine E, Murray Joseph C, Tihan Tarik, Jensen Michael C, Mischel Paul S, Stokoe David, Pieper Russell O

Abstract excerpt

Cancer immunoresistance and immune escape may play important roles in tumor progression and pose obstacles for immunotherapy. Expression of the immunosuppressive protein B7 homolog 1 (B7-H1), also known as programmed death ligand-1 (PD-L1), is increased in many pathological conditions, including cancer. Here we show that expression of the gene encoding B7-H1 increases post transcriptionally in human glioma after...

Read the complete abstract on PubMed

Topics

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Share to B7-H1 Antigen
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Ribosomal Protein S6 Kinases

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 17159987
DOI: 10.1038/nm1517

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.PMID 17159987Read ↗

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The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and SurvivalSemantic proximity Read ↗

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