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Article

Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.

Nature cell biology - 1 Nov 2008

Vitaliano-Prunier Adeline, Menant Alexandra, Hobeika Maria, Géli Vincent, Gwizdek Carole, Dargemont Catherine

Abstract excerpt

Mono-ubiquitylation of histone H2B correlates with transcriptional activation and is required for di- and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS methyltransferase complex through a poorly characterized trans-tail pathway. Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69 of Swd2, the essential component of SET1/COMPASS in...

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PMID: 18849979
DOI: 10.1038/ncb1796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.PMID 18849979Read ↗

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