Article
Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2000
Hughes T R, Weilbaecher R G, Walterscheid M, Lundblad V
Abstract excerpt
The CDC13 gene of Saccharomyces cerevisiae is required both to protect telomeric DNA and to ensure proper function of yeast telomerase in vivo. We have previously demonstrated that Cdc13p has a high affinity single-strand telomeric DNA binding activity, although the primary amino acid sequence of Cdc13p has no previously characterized DNA binding motifs. We report here mapping of the Cdc13 DNA binding domain by a...
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