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Article

FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.

The American journal of clinical nutrition - 1 Oct 2008

Martinelli Nicola, Girelli Domenico, Malerba Giovanni, Guarini Patrizia, Illig Thomas, Trabetti Elisabetta, Sandri Marco, Friso Simonetta, Pizzolo Francesca, Schaeffer Linda, Heinrich Joachim, Pignatti Pier Franco, Corrocher Roberto, Olivieri Oliviero

Abstract excerpt

BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA). Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Delta-5 Fatty Acid Desaturase

Share to Erythrocyte Membrane

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Share to Gene Expression Regulation, Enzymologic

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Source

Identifiers

PMID: 18842780
DOI: 10.1093/ajcn/88.4.941

Genes

CAD
FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.PMID 18842780Read ↗

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