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Article

SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.

Lipids - 1 Apr 2008

Malerba Giovanni, Schaeffer Linda, Xumerle Luciano, Klopp Norman, Trabetti Elisabetta, Biscuola Michele, Cavallari Ugo, Galavotti Roberta, Martinelli Nicola, Guarini Patrizia, Girelli Domenico, Olivieri Oliviero, Corrocher Roberto, Heinrich Joachim, Pignatti Pier Franco, Illig Thomas

Abstract excerpt

Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids. We have genotyped 13 single nucleotide polymorphisms (SNPs) located on the FADS1-FADS2-FADS3 gene cluster (chromosome 11q12-13.1) in 658 Italian adults (78% males; mean age 59.7 +/-...

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Source

Identifiers

PMID: 18320251
DOI: 10.1007/s11745-008-3158-5

Genes

FADS1
FADS2
FADS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.PMID 18320251Read ↗

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FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.Semantic proximity Read ↗

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.Semantic proximity Read ↗

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Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.Semantic proximity Read ↗

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