Article
Limited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer.
BMC cancer - 8 Oct 2008
Bragoszewski Piotr, Kupryjanczyk Jolanta, Bartnik Ewa, Rachinger Andrea, Ostrowski Jerzy
Abstract excerpt
BACKGROUND: In recent years, numerous studies have investigated somatic mutations in mitochondrial DNA in various tumours. The observed high mutation rates might reflect mitochondrial deregulation; consequently, mutation analyses could be clinically relevant. The purpose of this study was to determine if mutations in the mitochondrial D-loop region and/or the level of mitochondrial gene expression could influence...
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