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Article

A case-control study of peripheral blood mitochondrial DNA copy number and risk of renal cell carcinoma.

PloS one - 1 Jan 2012

Purdue Mark P, Hofmann Jonathan N, Colt Joanne S, Hoxha Mirjam, Ruterbusch Julie J, Davis Faith G, Rothman Nathaniel, Wacholder Sholom, Schwartz Kendra L, Baccarelli Andrea, Chow Wong-Ho

Abstract excerpt

BACKGROUND: Low mitochondrial DNA (mtDNA) copy number is a common feature of renal cell carcinoma (RCC), and may influence tumor development. Results from a recent case-control study suggest that low mtDNA copy number in peripheral blood may be a marker for increased RCC risk. In an attempt to replicate that finding, we measured mtDNA copy number in peripheral blood DNA from a U.S. population-based case-control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22937019
DOI: 10.1371/journal.pone.0043149
PMCID: PMC3427307

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