Article
Somatic mitochondrial DNA mutations in primary and metastatic ovarian cancer.
Gynecologic oncology - 1 Jan 2007
Van Trappen P O, Cullup T, Troke R, Swann D, Shepherd J H, Jacobs I J, Gayther S A, Mein C A
Abstract excerpt
OBJECTIVE: To date, most mtDNA mutations in cancer have been identified in the control region (D-loop) containing the major promoters. However, almost all studies used one sample per tumor and there is no clear evidence whether metastatic deposits harbor different mtDNA variants. To establish whether different mtDNA variants can be found in the same cancer but at different sites, we analyzed a series of...
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