Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women.

doi:10.1159/000160956

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Article

Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Fontalba Ana, Gutiérrez Olga, Llorca Javier, Mateo Ignacio, Berciano José, Fernández-Luna José Luis, Combarros Onofre

Abstract excerpt

NF-kappaB, a major transcription factor controlling inflammation, is activated in Alzheimer's disease (AD) brains. CARD8 protein has been implicated in the suppression of NF-kappaB activity, but a truncating polymorphism (p.C10X, rs2043211) renders a non-functional CARD8 protein that gives rise to a more active NF-kappaB and an amplification of the inflammatory process. Apolipoprotein E (ApoE) epsilon4 allele,...

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Identifiers

PMID: 18841008
DOI: 10.1159/000160956

Genes

CARD8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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