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Article

CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Apr 2010

Kastbom Alf, Johansson Martin, Verma Deepti, Söderkvist Peter, Rantapää-Dahlqvist Solbritt

Abstract excerpt

OBJECTIVES: CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. METHODS: CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Identifiers

PMID: 19443463
DOI: 10.1136/ard.2008.106989

Genes

CARD8
NLRP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis.PMID 19443463Read ↗

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