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Article

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China.

BioMed research international - 1 Jan 2020

Yu Pei, Liu Bingmei, Hao Siyu, Xing Ronggui, Li Yuzhen

Abstract excerpt

Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κB) activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic variants of CARD8 have been associated with an increased risk of several inflammatory diseases and psoriasis in Europe. However, nothing is known about the...

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Identifiers

PMID: 32104685
DOI: 10.1155/2020/2867505
PMCID: PMC7036091

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