Article
Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2005
Johansson Annica, Zetterberg Henrik, Hampel Harald, Buerger Katharina, Prince Jonathan A, Minthon Lennart, Wahlund Lars-Olof, Blennow Kaj
Abstract excerpt
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate...
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