Article
Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis.
Experimental dermatology - 1 Aug 2007
Macaluso Filippina, Nothnagel Michael, Parwez Qumar, Petrasch-Parwez Elisabeth, Bechara Falk Georges, Epplen Joerg Thomas, Hoffjan Sabine
Abstract excerpt
Atopic dermatitis (AD) is a chronic skin disease affecting up to 15% of children in industrialized countries. AD belongs to the group of atopic disorders characterized by excessive immune reactions to ubiquitous antigens. Complex interactions between genetic and environmental factors have been suggested for atopic disorders. Dysregulation of the innate immune system appears crucial for the pathogenesis of AD. The...
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