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Article

Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Fontalba Ana, Martinez-Taboada Victor, Gutierrez Olga, Pipaon Carlos, Benito Natividad, Balsa Alejandro, Blanco Ricardo, Fernandez-Luna Jose L

Abstract excerpt

Caspase activating and recruitment domain 8 (CARD8) potently inhibits NF-kappaB signaling, which plays a key role in inflammation, and may contribute to avoid a pathologic activation of NF-kappaB; however, the transcriptional mechanisms regulating CARD8 expression and the relevance of this protei...

Read the complete abstract on PubMed

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Share to Arthritis, Rheumatoid
Share to CARD Signaling Adaptor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17878386
DOI: 10.4049/jimmunol.179.7.4867

Genes

CARD8
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878386-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.PMID 17878386Read ↗

Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women.Semantic proximity Read ↗

Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease.Semantic proximity Read ↗

CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis.Semantic proximity Read ↗

Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis.Semantic proximity Read ↗

Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study.Semantic proximity Read ↗

Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.Semantic proximity Read ↗

Association of CARD8 with inflammatory bowel disease in Koreans.Semantic proximity Read ↗

Caspase recruitment domain (CARD) as a bi-functional switch of caspase regulation and NF-kappaB signals.Semantic proximity Read ↗

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China.Semantic proximity Read ↗

A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid ArthritisSemantic proximity Read ↗

PSORS2 is due to mutations in CARD14.Semantic proximity Read ↗

Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11).Semantic proximity Read ↗

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