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CARD8 polymorphism rs2043211 protects against noise-induced hearing loss by causing the dysfunction of CARD8 protein.

Environmental science and pollution research international - 1 Feb 2021

Miao Long, Wang Boshen, Ji Jiahui, Wan Liu, Yin Lihong, Zhu Baoli, Zhang Juan, Pu Yuepu

Abstract excerpt

Inflammation is a complicated process and is considered to be responsible for the development of noise-induced hearing loss (NIHL). CARD8 is an important component of inflammasome that has been implicated in inflammation. To decide the relationship between the polymorphisms of CARD8 gene and NIHL risk and deduce the potential mechanism, three SNPs (rs2043211, rs1062808, and rs12459322) were genotyped in a Chinese...

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PMID: 33067783
DOI: 10.1007/s11356-020-11193-1

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