High-throughput multiplex HLA-typing by ligase detection reaction (LDR) and universal array (UA) approach.

Abstract excerpt

One major goal of genetic research is to understand the role of genetic variation in living systems. In humans, by far the most common type of such variation involves differences in single DNA nucleotides, and is thus termed single nucleotide polymorphism (SNP). The need for improvement in throughput and reliability of traditional techniques makes it necessary to develop new technologies. Thus the past few years...

Topics

• Genome, Human
• HLA Antigens
• Histocompatibility Testing
• Humans
• Oligonucleotide Array Sequence Analysis
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide