New labelling technology for molecular probes applied to the ligation detection reaction-universal array system.

doi:10.1007/s12033-010-9305-2

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Article

New labelling technology for molecular probes applied to the ligation detection reaction-universal array system.

Molecular biotechnology - 1 Jan 2011

Lauri Andrea, Chessa Stefania, Raschetti Marta, Castiglioni Bianca, Mariani Paola, Caetano Alexandre R

Abstract excerpt

The ligation detection reaction (LDR) associated with universal arrays (UA) uses a fluorescently labelled probe (DP) and a Zip Code-extended probe to detect single nucleotide polymorphisms in DNA target sequences. When used for genotyping, the LDR-UA technique uses two DPs, each specific to an allele and labelled with a different fluorophore. The fluorescent signals are processed to calculate the genotype. The...

Topics

Alleles
Base Sequence
Genotype
Molecular Probes
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

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Identifiers

PMID: 20577831
DOI: 10.1007/s12033-010-9305-2

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