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Article

Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology.

Glia - 1 Apr 2009

Rhee Wootack, Ray Sutapa, Yokoo Hideaki, Hoane Megan E, Lee Chong C, Mikheev Andrei M, Horner Philip J, Rostomily Robert C

Abstract excerpt

The capacity of adult human glial progenitor cells (AGPs), to proliferate and undergo multipotent differentiation, positions them as ideal candidate cells of origin for human gliomas. To investigate this potential role we identified AGPs as mitotically active Olig2 cells in nonneoplastic adult human brain and gliomas. We conservatively estimated that one in 5,000 human temporal lobe neocortical gray or...

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Identifiers

PMID: 18837053
DOI: 10.1002/glia.20780
PMCID: PMC4415884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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