Article
NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.
Neuro-oncology - 1 Aug 2011
Al-Mayhani M Talal F, Grenfell Richard, Narita Masashi, Piccirillo Sara, Kenney-Herbert Emma, Fawcett James W, Collins V Peter, Ichimura Koichi, Watts Colin
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common type of primary brain tumor and a highly malignant and heterogeneous cancer. Current conventional therapies fail to eradicate or curb GBM cell growth. Hence, exploring the cellular and molecular basis of GBM cell growth is vital to develop novel therapeutic approaches. Neuroglia (NG)-2 is a transmembrane proteoglycan expressed by NG2+ progenitors and is strongly...
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