Article

Cell type-specific isolation and transcriptomic profiling informs glial pathology in human temporal lobe epilepsy

2020-12-12

Abstract excerpt

<h4>SUMMARY</h4> The pathophysiology of epilepsy underlies complex network dysfunction, the cell-type-specific contributions of which remain poorly defined in human disease. In this study, we developed a strategy that simultaneously isolates neuronal, astrocyte and oligodendroglial progenitor (OPC)-enriched nuclei from human fresh-frozen neocortex and applied it to characterize the distinct transcriptome of each...

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Literature Corpus work: 098f0a38-85c3-53a8-ab5b-711d7d71924e
DOI: 10.1101/2020.12.11.421370

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