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Article

Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.

Cell reports - 12 Dec 2013

Zhang Zhi-Min, Yang Fei, Zhang Jinru, Tang Qing, Li Jie, Gu Jing, Zhou Jiahai, Xu Yong-Zhen

Abstract excerpt

The DEAD-box adenosine triphosphatase (ATPase) Prp5p facilitates U2 small nuclear ribonucleoprotein particle (snRNP) binding to the intron branch site region during spliceosome assembly. We present crystal structures of S. cerevisiae Prp5p alone and in complex with ADP at 2.12 Å and 1.95 Å resolution. The three-dimensional packing of Prp5p subdomains differs strikingly from that so far observed in other DEAD-box...

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Identifiers

PMID: 24290758
DOI: 10.1016/j.celrep.2013.10.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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