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Article

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta.

Biochemical and biophysical research communications - 19 Dec 2008

Kabuta Tomohiro, Take Kazumi, Kabuta Chihana, Hakuno Fumihiko, Takahashi Shin-ichiro

Abstract excerpt

Insulin receptor substrates (IRSs) play essential roles in signal transduction of insulin and insulin-like growth factors. Previously, we showed that IRS-3 is localized to the nucleus as well as the cytosol, while IRS-1 and 2 are mainly localized to the cytoplasm. In the present study, we found that importin beta directly interacts with IRS-3 and is able to mediate nuclear transport of IRS-3. Importin beta...

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Identifiers

PMID: 18835249
DOI: 10.1016/j.bbrc.2008.09.106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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