Article
Characterization of the nuclear import pathways of galectin-3.
Cancer research - 15 Oct 2006
Nakahara Susumu, Oka Natsuo, Wang Yi, Hogan Victor, Inohara Hidenori, Raz Avraham
Abstract excerpt
Galectin-3 (Gal-3), a pleiotropic beta-galactoside-binding protein, was shown to be involved in several nuclear-dependent functions, including up-regulation of transcriptional factors, RNA processing, and cell cycle regulation. Gal-3 compartmentalization in the nucleus versus the cytoplasm affects, in part, the malignant phenotype of various cancers. However, to date, the mechanism by which Gal-3 translocates...
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