Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit.

The Journal of biological chemistry - 4 Aug 2000

Schedlich L J, Le Page S L, Firth S M, Briggs L J, Jans D A, Baxter R C

Abstract excerpt

Although insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 are known to modulate cell growth by reversibly sequestering extracellular insulin-like growth factors, several reports have suggested that IGFBP-3, and possibly also IGFBP-5, have important insulin-like growth factor-independent effects on cell growth. These effects may be related to the putative nuclear actions of IGFBP-3 and IGFBP-5,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Guanosine Triphosphate

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Karyopherins

Share to Nuclear Localization Signals

Share to Peptide Fragments

Source

Identifiers

PMID: 10811646
DOI: 10.1074/jbc.M002208200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit.PMID 10811646Read ↗

Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.Semantic proximity Read ↗

Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3.Semantic proximity Read ↗

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor CellsSemantic proximity Read ↗

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta.Semantic proximity Read ↗

Importin-mediated nuclear translocation of galectin-3.Semantic proximity Read ↗

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.Semantic proximity Read ↗

Characterization of the nuclear import pathways of galectin-3.Semantic proximity Read ↗

Transport of galectin-3 between the nucleus and cytoplasm. I. Conditions and signals for nuclear import.Semantic proximity Read ↗

The nuclear import of protein kinase D3 requires its catalytic activity.Semantic proximity Read ↗

IGF-Binding Protein-3-Induced Growth Inhibition and Apoptosis Do Not Require Cell Surface Binding and Nuclear Translocation in Human Breast Cancer CellsSemantic proximity Read ↗

Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3.Semantic proximity Read ↗

The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.